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dc.contributor.authorNabila, Aisyah
dc.date.accessioned2025-07-08T02:58:29Z
dc.date.available2025-07-08T02:58:29Z
dc.date.issued2025-01-12
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dc.identifier.urihttps://dspace.umkt.ac.id//handle/463.2017/4983
dc.description.abstractLatar Belakang: Peradangan merupakan respons alami tubuh terhadap cedera jaringan, ditandai dengan pelepasan mediator inflamasi seperti Interleukin-6 (IL-6) dan Tumor Necrosis Factor-alpha (TNF-α). Kedua mediator ini memiliki peran penting dalam mengatur respons imun tubuh. Namun, produksi berlebihan dapat memicu badai sitokin, yang berpotensi menyebabkan kerusakan organ, sebagaimana terlihat pada beberapa kasus pasien COVID-19. Penggunaan obat antiinflamasi nonsteroid (NSAID) sering kali menimbulkan efek samping, sehingga bahan alami seperti propolis muncul sebagai alternatif yang menjanjikan. Propolis, yang mengandung senyawa aktif Caffeic Acid Phenethyl Ester (CAPE), diketahui memiliki aktivitas antiinflamasi dengan menghambat sintesis mediator inflamasi, memperkuat imunitas seluler, dan mempercepat penyembuhan jaringan. Untuk mengeksplorasi mekanisme interaksi ini secara mendalam, pendekatan molecular docking digunakan untuk memprediksi potensi CAPE sebagai agen antiinflamasi yang aman dan efektif. Tujuan: Penelitian ini bertujuan untuk menganalisis potensi senyawa Caffeic Acid Phenethyl Ester (CAPE) terhadap protein target Interleukin-6 (IL-6) dan Tumor Necrosis Factor-alpha (TNF-α) melalui pengukuran nilai binding affinity dan interaksi molekuler menggunakan pendekatan molecular docking, guna mengevaluasi perannya sebagai agen antiinflamasi. Hasil Penelitian: Senyawa pembanding menunjukkan nilai binding affinity yang lebih unggul dibandingkan dengan senyawa uji. Meskipun senyawa uji memperlihatkan interaksi dengan residu asam amino pada protein targetnya, hasil penelitian menunjukkan bahwa senyawa uji memiliki potensi yang lebih rendah dalam proses docking terhadap protein target IL-6 dan TNF-α. Hal ini menyimpulkan bahwa senyawa uji kurang efektif sebagai agen antiinflamasi dibandingkan dengan senyawa pembanding.id_ID
dc.language.isoidid_ID
dc.publisherUniversitas Muhammadiyah Kalimantan Timurid_ID
dc.subjectCaffeic Acid Phenethyl Ester (CAPE)id_ID
dc.subjectIL-6id_ID
dc.subjectTNF-αid_ID
dc.subjectAntiinflamasiid_ID
dc.titleANALISIS POTENSI SENYAWA CAFFEIC ACID PHENETHYL ESTER (CAPE) SEBAGAI ANTIINFLAMASI PADA PROTEIN TARGET IL-6 DAN TNF-α MELALUI STUDI MOLECULAR DOCKINGid_ID
dc.typeSkripsiid_ID


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